We propose to organize and conduct the Gordon Conference on Immunochemistry and Immunobiology to be held June 2-6, 1984. The themes for this Conference will include: 1. Regulation of immunoglobulin gene expression in vivo and in genetically engine configurations. 2. Organization of MHC genes and structure of their products. 3. The differentiation and development of T cells and the nature of T cell receptors for antigen. 4. The differentiation and development of B cells. 5. The physiological activity of lymphokines and other mediators of immunity. 6. The cell biology of hormone action in specific systems as models for mediators of immunity. 7. The cell biology of macrophages.